Gene description for PMEL
Gene name	premelanosome protein
Gene symbol	PMEL
Other names/aliases	D12S53E HMB-45 HMB45 ME20 ME20-M ME20M P1 P100 PMEL17 SI SIL SILV gp100
Species	Homo sapiens
Experiment description of studies that identified PMEL in Melanoma cells
1 Experiment ID 274 Identified molecule protein Extracellular vesicle type Microvesicles MISEV EVs Identification method Immunoelectron microscopy Western blotting FACS PubMed ID 12021310    Organism Homo sapiens Experiment description Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles Authors Andreola G, Rivoltini L, Castelli C, Huber V, Perego P, Deho P, Squarcina P, Accornero P, Lozupone F, Lugini L, Stringaro A, Molinari A, Arancia G, Gentile M, Parmiani G, Fais S Journal name J Exp Med Publication year 2002 Sample Melanoma cells Sample name Me15392 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Imunoelectron microscopy Western blotting FACS EV-TRACK -
2 Experiment ID 275 Identified molecule protein Extracellular vesicle type Microvesicles MISEV EVs Identification method Immunoelectron microscopy Western blotting FACS PubMed ID 12021310    Organism Homo sapiens Experiment description Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles Authors Andreola G, Rivoltini L, Castelli C, Huber V, Perego P, Deho P, Squarcina P, Accornero P, Lozupone F, Lugini L, Stringaro A, Molinari A, Arancia G, Gentile M, Parmiani G, Fais S Journal name J Exp Med Publication year 2002 Sample Melanoma cells Sample name 501mel Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Imunoelectron microscopy Western blotting FACS EV-TRACK -
3 Experiment ID 276 Identified molecule protein Extracellular vesicle type Microvesicles MISEV EVs Identification method Immunoelectron microscopy Western blotting FACS PubMed ID 12021310    Organism Homo sapiens Experiment description Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles Authors Andreola G, Rivoltini L, Castelli C, Huber V, Perego P, Deho P, Squarcina P, Accornero P, Lozupone F, Lugini L, Stringaro A, Molinari A, Arancia G, Gentile M, Parmiani G, Fais S Journal name J Exp Med Publication year 2002 Sample Melanoma cells Sample name Me30966 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Imunoelectron microscopy Western blotting FACS EV-TRACK -
4 Experiment ID 622 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry [LTQ] PubMed ID 27894104    Organism Homo sapiens Experiment description Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. Authors Hurwitz SN, Rider MA, Bundy JL, Liu X, Singh RK, Meckes DG Jr. Journal name Oncotarget Publication year 2016 Sample Melanoma cells Sample name SK-MEL-28 Isolation/purification methods Differential centrifugation Polymer-based precipitation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ] EV-TRACK -
5 Experiment ID 624 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry [LTQ] PubMed ID 27894104    Organism Homo sapiens Experiment description Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. Authors Hurwitz SN, Rider MA, Bundy JL, Liu X, Singh RK, Meckes DG Jr. Journal name Oncotarget Publication year 2016 Sample Melanoma cells Sample name UACC-257 Isolation/purification methods Differential centrifugation Polymer-based precipitation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ] EV-TRACK -